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- In Pandemic, several virulent diseases have broken out simultaneously all over the world!
- The players are disease-fighting specialists whose mission is to treat disease hotspots while researching cures for each of four plagues before they get out of hand.
- The game board depicts several major population centers on Earth. On each turn, a player can use up to four actions to travel between cities, treat infected populaces, discover a cure, or build a research station.
- A deck of cards provides the players with these abilities, but sprinkled throughout this deck are Epidemic! cards that accelerate and intensify the diseases' activity.
- Taking a unique role within the team, players must plan their strategy to mesh with their specialists' strengths in order to conquer the diseases.
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